I have used everything from a 53 gr Vmax out of my MVP, a 12 gauge, and my compound bow to kill coyotes. My bow with a rage 2 blade does the least pelt damage and can be sewn up easy. I love my MVP for killing out to the 300 yd range, but it blows some big holes coming out! I am encountering more coyotes close range in the timber and I am going to start experimenting with rimfire calibers to see about lethality and minimal pelt damage. I am confident I can take head shots with a suppressed 22lr rifle under 50 yds, but not sure how they efficient it will be on vital shots. Any one currently using a rimfire cartridge or have experience hunting coyotes with rimfire cartridges?